反应详情

A solution of the product of Example 157B (0.386 g, 1.0 mmol) in ethanol (5 mL) was treated with 21% sodium ethoxide in ethanol (0.324 g, 1.0 mmol), stirred for 30 minutes and partitioned between ethyl acetate and 5% aqueous HCl and the layers were separated. The ethyl acetate layer was washed with brine, dried (Na2SO4), and concentrated to provide the title compound (0.28 g, 82%). MS (DCI) m/z 341(M+H)+.

1. custompartitioned between ethyl acetate and 5% aqueous HCl
2. customthe layers were separated
3. washThe ethyl acetate layer was washed with brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated