反应详情

The product of Example 307A (1.42 g, 3.79 mmol) in tetrahydrofuran (60 mL) was reacted with 10% palladium on carbon (0.2 g) under hydrogen atmosphere for 16 hours at 25° C. The reaction mixture was filtered and concentrated under reduced pressure to an oil. The residue was purified on silica gel eluting with ethyl acetate to give the title compound as of a white solid (0.8 g).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated under reduced pressure to an oil
3. customThe residue was purified on silica gel eluting with ethyl acetate