3-Methylbutanal → 3-(1,1-dioxo-7-phenylmethoxy-4H-1lambda6,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-[(E)-3-methylbutylideneamino]quinolin-2-one

Participants

Reaction Conditions

Reaction Steps

The product of Example 304F (0.220 g, 0.48 mmol) and isovaleraldehyde (0.77 mL, 7.18 mmol) in N,N-dimethylacetamide (1.5 mL) were reacted at 130° C. for 35 minutes in a microwave reactor in a sealed tube. The reaction was concentrated under a stream of nitrogen warmed through a manifold heated to 165° C. The resulting residue was triturated with diethyl ether and filtered to give the title compound (0.181 g, 72%).

Provenance & Evidence