反应详情

温度

165 °C

The product of Example 304F (0.220 g, 0.48 mmol) and isovaleraldehyde (0.77 mL, 7.18 mmol) in N,N-dimethylacetamide (1.5 mL) were reacted at 130° C. for 35 minutes in a microwave reactor in a sealed tube. The reaction was concentrated under a stream of nitrogen warmed through a manifold heated to 165° C. The resulting residue was triturated with diethyl ether and filtered to give the title compound (0.181 g, 72%).

1. concentrationThe reaction was concentrated under a stream of nitrogen
2. temperaturewarmed through a manifold
3. customThe resulting residue was triturated with diethyl ether
4. filtrationfiltered