反应详情

温度

25 °C

The product of Example 304F (0.1 g, 0.22 mmol) in N,N-dimethylacetamide (1 mL) was reacted with propionaldehyde diethylacetal (0.34 mL, 2.2 mmol) in a sealed tube in a microwave reactor at 100° C. for 60 minutes. The reaction was cooled to 25° C., concentrated under a stream of nitrogen warmed through a manifold heated to 165° C. and the resulting residue was triturated with diethyl ether to give the title compound (0.045 g, 42%).

1. concentrationconcentrated under a stream of nitrogen
2. temperaturewarmed through a manifold
3. temperatureheated to 165° C.
4. customthe resulting residue was triturated with diethyl ether