Hydrochloric Acid → HCID 135410990, compound

HRID 601423Notes

Reaction equation

HRID 601423 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:4](=[O:17])[C:3]=1[C:18]1[NH:23][C:22]2[CH:24]=[CH:25][C:26]([NH:28][S:29]([NH:32][CH2:33][CH2:34][NH:35]C(=O)OC(C)(C)C)(=[O:31])=[O:30])=[CH:27][C:21]=2[S:20](=[O:44])(=[O:43])[N:19]=1.Cl>O1CCOCC1>[NH2:35][CH2:34][CH2:33][NH:32][S:29]([NH:28][C:26]1[CH:25]=[CH:24][C:22]2[NH:23][C:18]([C:3]3[C:4](=[O:17])[N:5]([CH2:12][CH2:13][CH:14]([CH3:16])[CH3:15])[C:6]4[C:11]([C:2]=3[OH:1])=[CH:10][CH:9]=[CH:8][N:7]=4)=[N:19][S:20](=[O:43])(=[O:44])[C:21]=2[CH:27]=1)(=[O:30])=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136358519HCID 136358519, compound

Product 1

HCID 135410990HCID 135410990, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of the product of Example 459A (0.0053 g, 0.0082 mmol) in a solution of hydrogen chloride in 1,4-dioxane (4 N, 3 mL) and stirred at 25° C. and stirred for 18 hours. The solvent was removed under reduced pressure to give the title compound as the hydrochloride salt (4 mg, 89%). 1H NMR (300 MHz, DMSO-d6) δ 0.99 (d, J=6.62 Hz, 6 H) 1.56 (m, 2 H) 1.68 (m, 1 H) 2.89 (m, 2 H) 3.10 (m, 2 H) 4.49 (m, 2 H) 7.51 (m, 2 H) 7.62 (d, J=2.21 Hz, 1 H) 7.74 (d, J=8.82 Hz, 1 H) 7.79 (s, 2 H) 8.03 (t, J=5.70 Hz, 1 H) 8.56 (dd, J=7.72, 1.84 Hz, 1 H) 8.89 (dd, J=4.41, 1.84 Hz, 1 H) 10.37 (s, 1 H) 14.16 (s, 1 H). MS (ESI−) m/z 548 (M−H)−.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-3d0a8d2a60b84660994d6e5fbbfd2489
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Reaction notes

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