反应详情

A stirred mixture of 3-fluoro-4-methanesulfonyl-benzaldehyde (Example AA1) (24 g, 0.119 mol), nitroethane (70 ml, 0.97 mol) and ammonium acetate (2.75 g, 35 mmol) is heated at reflux under argon for 24 hours. The mixture is concentrated to give an oil which is dissolved in chloroform (200 ml) and washed with water (2×200 ml), followed by brine (100 ml). The organic extract is dried (MgSO4), filtered and the solvent removed to give the product as an orange oil. This was used immediately in the next step.

1. temperatureis heated
2. temperatureat reflux under argon for 24 hours
3. concentrationThe mixture is concentrated
4. customto give an oil which
5. washwashed with water (2×200 ml)
6. extractionThe organic extract
7. dry with materialis dried (MgSO4)
8. filtrationfiltered
9. customthe solvent removed