5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine → 5-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine

HRID 601617Notes

Reaction equation

HRID 601617 reaction equation
FC1C=C([C:12]2[S:16][C:15]([NH2:17])=[N:14][C:13]=2[CH3:18])C=CC=1S(C)(=O)=O.[F:19][C:20]1[CH:21]=[C:22](CC(=O)C)[CH:23]=[CH:24][C:25]=1[S:26]([CH3:29])(=[O:28])=[O:27].FC1C=CC(CC(=O)C)=CC=1S(C)(=O)=O>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([C:12]2[S:16][C:15]([NH2:17])=[N:14][C:13]=2[CH3:18])=[CH:24][C:25]=1[S:26]([CH3:29])(=[O:27])=[O:28]

Participants

4

Reactant 3

HCID 573512775-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amineHCID 573512781-(3-Fluoro-4-(methylsulfonyl)phenyl)propan-2-oneHCID 574668151-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-one

Product 1

HCID 574737505-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine

Procedure

The titled compound is prepared via an analogous method to 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Intermediate AA) by replacing 1-(3-fluoro-4-methanesulfonyl-phenyl)-propan-2-one (AA3) in step AA4 with 1-(4-fluoro-3-methanesulfonyl-phenyl)-propan-2-one (AG3).

Sources & evidence

ORD record
ord-72b602a5d3864dfd97f15422ed49d547
Source dataset
uspto-grants-2011_03
Patent number
US07902375B2

Reaction notes

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