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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 601617Generated: October 26, 2026

5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine → 5-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine

https://huagongshe.com/reaction/601617

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amineHCID 57351277—
Reactant1-(3-Fluoro-4-(methylsulfonyl)phenyl)propan-2-oneHCID 57351278—
Reactant1-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-oneHCID 57466815—
Product5-(4-Fluoro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamineHCID 57473750—

Reaction Steps

The titled compound is prepared via an analogous method to 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Intermediate AA) by replacing 1-(3-fluoro-4-methanesulfonyl-phenyl)-propan-2-one (AA3) in step AA4 with 1-(4-fluoro-3-methanesulfonyl-phenyl)-propan-2-one (AG3).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07902375B2
Source datasetuspto-grants-2011_03
ORD IDord-72b602a5d3864dfd97f15422ed49d547
Source noteuspto-grants-2011_03