1,1-Dimethoxyethyl(dimethyl)amine → HCID 86624590, compound

HRID 601626Notes

Reaction equation

HRID 601626 reaction equation
CO[C:3](OC)([N:5]([CH3:7])[CH3:6])[CH3:4].[C:10]([O:14][C:15](=[O:22])[NH:16][CH2:17][CH2:18][C:19](=[S:21])[NH2:20])([CH3:13])([CH3:12])[CH3:11]>C(Cl)Cl>[C:10]([O:14][C:15](=[O:22])[NH:16][CH2:17][CH2:18][C:19](=[S:21])[N:20]=[C:3]([N:5]([CH3:7])[CH3:6])[CH3:4])([CH3:13])([CH3:11])[CH3:12]

Participants

4

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 2735653tert-Butyl (3-amino-3-sulfanylidenepropyl)carbamate

Product 1

HCID 86624590HCID 86624590, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dimethylacetamide dimethylacetal (1.56 g, 11.7 mmol) is added to a stirred solution of (2-thiocarbamoyl-ethyl)-carbamic acid tert-butyl ester (1.0 g, 4.9 mmol) in DCM (50 ml). The reaction is stirred for 24 hours at room temperature followed by removal of the solvent. The residue is purified by chromatography on silica, eluting with ethyl acetate-diethyl ether (1:1) to give the titled compound as a yellow oil.

Workup

  1. customfollowed by removal of the solvent
  2. customThe residue is purified by chromatography on silica
  3. washeluting with ethyl acetate-diethyl ether (1:1)

Sources & evidence

ORD record
ord-347c3aa54b104c598ce0deef00bde2b1
Source dataset
uspto-grants-2011_03
Patent number
US07902375B2

Reaction notes

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