Trifluoroacetic acid → 2-(5-Methyl-1,3,4-oxadiazol-2-yl)ethanamine

HRID 601630Notes

Reaction equation

HRID 601630 reaction equation
C(O)(C(F)(F)F)=O.C(OC(=O)[NH:14][CH2:15][CH2:16][C:17]1[O:18][C:19]([CH3:22])=[N:20][N:21]=1)(C)(C)C>C(Cl)Cl>[CH3:22][C:19]1[O:18][C:17]([CH2:16][CH2:15][NH2:14])=[N:21][N:20]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10013959HCID 10013959, compound

Product 1

HCID 100578482-(5-Methyl-1,3,4-oxadiazol-2-yl)ethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1 ml) is added to a stirred solution of [2-(5-methyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (0.077 g, 0.34 mmol) in DCM (5 ml). After 1 hour at room temperature the solvents are removed. The residue is dissolved in DCM and washed with 4M aqueous NaOH solution. The organic extract is separated, dried (MgSO4) and the solvent removed to give the titled compound.

Workup

  1. customAfter 1 hour at room temperature the solvents are removed
  2. dissolutionThe residue is dissolved in DCM
  3. washwashed with 4M aqueous NaOH solution
  4. extractionThe organic extract
  5. customis separated
  6. dry with materialdried (MgSO4)
  7. customthe solvent removed

Sources & evidence

ORD record
ord-ede7b416bf534ee8993bdfd14a4ef93f
Source dataset
uspto-grants-2011_03
Patent number
US07902375B2

Reaction notes

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