反应详情

Under nitrogen atmosphere, 0.2 ml of trifluoromethansulfonic anhydride was added at 0° C. to 3 ml solution of pyridine with 10 mg of 7-hydroxy-2-methyl-4H-chromen-4-one, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution, extracted with ethyl acetate. Ethyl acetate layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. The solvents were distilled outunder reduced pressure, and the residues were separated and purified by silicagel chromatography (hexane/ethyl acetate=10/1) to obtain 112 mg of the above compound as a white solid.

1. extractionextracted with ethyl acetate
2. washEthyl acetate layer was washed with saturated saline solution
3. dry with materialdried with anhydrous sodium sulfate
4. distillationThe solvents were distilled outunder reduced pressure
5. customthe residues were separated
6. custompurified by silicagel chromatography (hexane/ethyl acetate=10/1)