反应详情

温度

110 °C

Under nitrogen atmosphere, 180 mg of N-methylisopropylamine, and 200 g of potassium carbonate were added at room temperature sequentially to 5 ml solution of dimethylsulfonamide with 63 g of 2-chloro-6-bromoquinoline, and the mixture was stirred at 110° C. for 4 hours. Water was added to the reaction solution, extracted with ethyl acetate. Ethyl acetate layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. The solvents were distilled outunder reduced pressure, and the residues were separated and purified by silicagel chromatography (hexane/ethyl acetate=3/1) to obtain 18 mg of the above compound as a white solid.

1. extractionextracted with ethyl acetate
2. washEthyl acetate layer was washed with saturated saline solution
3. dry with materialdried with anhydrous sodium sulfate
4. distillationThe solvents were distilled outunder reduced pressure
5. customthe residues were separated
6. custompurified by silicagel chromatography (hexane/ethyl acetate=3/1)