Formic Acid → HCID 178421863, compound

HRID 601668Notes

Reaction equation

[CH:1]1([N:4]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:13]4[N:14]=[N:15][N:16]([C:19]5[C:20](F)=[N:21][CH:22]=[CH:23][CH:24]=5)[C:17]=4[CH3:18])[CH:10]=3)[C:5]2=[O:26])[CH2:3][CH2:2]1.C(O)=[O:28]>>[CH:1]1([N:4]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:13]4[N:14]=[N:15][N:16]([C:19]5[C:20]([OH:28])=[N:21][CH:22]=[CH:23][CH:24]=5)[C:17]=4[CH3:18])[CH:10]=3)[C:5]2=[O:26])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 284Formic Acid

HCID 11175501HCID 11175501, compound

Product 1

HCID 178421863HCID 178421863, compound

Procedure

180 mg of 4-(2-cyclopropyl-1-oxo-isoindoline-5-yl)-1-(2-fluoropyridine-3-yl)-5-methyl-1H-[1,2,3]triazole obtained in Example 49 was dissolved in 10 ml of formic acid, and the mixture was stirred for 5 hours. After cooling down to room temperature, the residues obtained by distilling out the solvents under reduced pressure were purified by silicagel column chromatography (chloroform:methanol=90:10) to obtain 112 mg of the above compound as a white solid.

Workup

customthe residues obtained
distillationby distilling out the solvents under reduced pressure
customwere purified by silicagel column chromatography (chloroform:methanol=90:10)

Sources & evidence

ORD record: ord-c01d5b392f684645a180167cdbaf15ac
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902369B2

Reaction notes

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