Formic Acid → HCID 178421863, compound

Participants

Reaction Steps

180 mg of 4-(2-cyclopropyl-1-oxo-isoindoline-5-yl)-1-(2-fluoropyridine-3-yl)-5-methyl-1H-[1,2,3]triazole obtained in Example 49 was dissolved in 10 ml of formic acid, and the mixture was stirred for 5 hours. After cooling down to room temperature, the residues obtained by distilling out the solvents under reduced pressure were purified by silicagel column chromatography (chloroform:methanol=90:10) to obtain 112 mg of the above compound as a white solid.

Provenance & Evidence