Acetone → 86347-15-1

HRID 601698Notes

Reaction equation

HRID 601698 reaction equation
O.[ClH:2].[CH3:3][C:4]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:5]=1[CH:11]([C:13]1[NH:17][CH:16]=[N:15][CH:14]=1)[CH3:12].CC(C)=O>O>[ClH:2].[CH3:3][C:4]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:5]=1[CH:11]([C:13]1[NH:17][CH:16]=[N:15][CH:14]=1)[CH3:12]

Participants

4

Reactant 2

HCID 180AcetoneHCID 67315851HCID 67315851, compound

Product 1

HCID 6860186347-15-1

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
57 °C

Procedure

5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride hydrate (89 g), acetone (855 mL) and water (34 mL) were mixed in a 2-liter flask, fitted with a thermometer and a reflux condenser. The reaction mixture was heated to 56-58° C. for 15 minutes, at which point it was filtered. The filtrate was at first cooled to 20-30° C. over 1 to 1.5 hours, and then it was cooled to 0 to −10)° C. for 2.5 to 3.5 hours.

Workup

  1. customfitted with a thermometer and a reflux condenser
  2. filtrationwas filtered
  3. temperatureat first cooled to 20-30° C. over 1 to 1.5 hours
  4. temperatureit was cooled to 0 to −10)° C

Sources & evidence

ORD record
ord-555e9c431a8246bd8dd325640d770273
Source dataset
uspto-grants-2011_03
Patent number
US07902377B2

Reaction notes

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