Acetone → 86347-15-1

Participants

Reaction Conditions

Reaction Steps

5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride hydrate (89 g), acetone (855 mL) and water (34 mL) were mixed in a 2-liter flask, fitted with a thermometer and a reflux condenser. The reaction mixture was heated to 56-58° C. for 15 minutes, at which point it was filtered. The filtrate was at first cooled to 20-30° C. over 1 to 1.5 hours, and then it was cooled to 0 to −10)° C. for 2.5 to 3.5 hours.

Provenance & Evidence