Lithium hydroxide, monohydrate → HCID 44125251, compound

Participants

Reaction Steps

The title compound was synthesized from methyl 5,5-difluoro-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate and lithium hydroxide monohydrate according to General Procedure 7. The material was purified by reverse-phase chromatography (MeCN/H2O, 0.05% TFA) to afford 1.6 mg of 5,5-difluoro-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid in 45.0% yield. 19F NMR (400 MHz, acetone-d6) δ ppm −86.73; LCMS-MS (ESI+) 188.0 (M+H).

Provenance & Evidence