Lithium hydroxide, monohydrate → HCID 44125251, compound

HRID 601891Notes

Reaction equation

HRID 601891 reaction equation
[F:1][C:2]1([F:14])[CH2:13][C:5]2[NH:6][C:7]([C:9]([O:11]C)=[O:10])=[CH:8][C:4]=2[CH2:3]1.O.[OH-].[Li+]>>[F:14][C:2]1([F:1])[CH2:13][C:5]2[NH:6][C:7]([C:9]([OH:11])=[O:10])=[CH:8][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 59180200HCID 59180200, compound

Product 1

HCID 44125251HCID 44125251, compound

Procedure

The title compound was synthesized from methyl 5,5-difluoro-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate and lithium hydroxide monohydrate according to General Procedure 7. The material was purified by reverse-phase chromatography (MeCN/H2O, 0.05% TFA) to afford 1.6 mg of 5,5-difluoro-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid in 45.0% yield. 19F NMR (400 MHz, acetone-d6) δ ppm −86.73; LCMS-MS (ESI+) 188.0 (M+H).

Workup

  1. customThe material was purified by reverse-phase chromatography (MeCN/H2O, 0.05% TFA)

Sources & evidence

ORD record
ord-c9fa67c954ef431ca792c3d34ad39a45
Source dataset
uspto-grants-2011_03
Patent number
US07902252B2

Reaction notes

Loading…