Lithium hydroxide, monohydrate → 6-Oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

HRID 601900Notes

Reaction equation

HRID 601900 reaction equation
[O:1]=[C:2]1[C:6]2[NH:7][C:8]([C:10]([O:12]CC)=[O:11])=[CH:9][C:5]=2[CH2:4][CH2:3]1.O.[OH-].[Li+]>>[O:1]=[C:2]1[C:6]2[NH:7][C:8]([C:10]([OH:12])=[O:11])=[CH:9][C:5]=2[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 57659859Ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

Product 1

HCID 576598406-Oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

Procedure

The title compound was synthesized from ethyl 6-oxo-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate (90 mg, 0.47 mmol) and lithium hydroxide monohydrate (78 mg, 1.86 mmol) according to General Procedure 7 (56 mg, 77%). 1H NMR (400 MHz, METHANOL-d4) δ ppm 2.84-2.91 (4H), 6.73 (s, 1H); LCMS-MS (ESI+) 165.8 (M+H); HPLC (UV=100%), (ELSD=100%).

Sources & evidence

ORD record
ord-1e428bc744ce4da29074bffe6cd7e150
Source dataset
uspto-grants-2011_03
Patent number
US07902252B2

Reaction notes

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