Hydrochloric Acid → HCID 57445721, compound

HRID 602017Notes

Reaction equation

HRID 602017 reaction equation
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[F:17])[C:2]#[CH:3].[OH-].[Na+].Cl>C(O)C>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[F:17])[C:2]#[CH:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59301817HCID 59301817, compound

Product 1

HCID 57445721HCID 57445721, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 50 ml of ethanol were added 10.8 g of 2-propynyl 4-(2-propynyloxy)-3-fluorobenzoate and 30 ml of 15% aqueous sodium hydroxide solution and the mixture obtained was stirred at room temperature for 2 hours. Then, the reaction mixture was added to hydrochloric acid for acidification. Crystals precipitated were collected by filtration and dried to obtain 8.0 g of 4-(2-propynyloxy)-3-fluorobenzoic acid represented by the formula:

Workup

  1. customthe mixture obtained
  2. customCrystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-8f72147b874c4913b84daaf4cb98595b
Source dataset
uspto-grants-2011_03
Patent number
US07902400B2

Reaction notes

Loading…