反应详情

温度

50 °C

To 10 ml of ethanol were added 2.2 g of 2-propynyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 6 ml of 15% aqueous sodium hydroxide solution, and the mixture obtained was stirred at 50° C. for 1 hour. Then, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue for acidification. Crystals precipitated were collected by filtration and dried to obtain 1.8 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid.

1. customthe mixture obtained
2. concentrationThen, the reaction mixture was concentrated under reduced pressure
3. additionHydrochloric acid was added to the residue for acidification
4. customCrystals precipitated
5. filtrationwere collected by filtration
6. customdried