HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 602027Generated: October 25, 2026
Sodium Hydroxide → 3,5-Difluoro-4-(2-propynyloxy)benzoic acid
https://huagongshe.com/reaction/602027
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Propynyl 3,5-difluoro-4-(2-propynyloxy)benzoate | HCID 59301790 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-Difluoro-4-(2-propynyloxy)benzoic acid | HCID 57445666 | 96.5% |
Reaction Steps
To 10 ml of ethanol were added 2.2 g of 2-propynyl 3,5-difluoro-4-(2-propynyloxy)benzoate and 6 ml of 15% aqueous sodium hydroxide solution, and the mixture obtained was stirred at 50° C. for 1 hour. Then, the reaction mixture was concentrated under reduced pressure. Hydrochloric acid was added to the residue for acidification. Crystals precipitated were collected by filtration and dried to obtain 1.8 g of 3,5-difluoro-4-(2-propynyloxy)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07902400B2 |
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| Source dataset | uspto-grants-2011_03 |
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| ORD ID | ord-34d0e5df0bac46a7a9a9cf4c7541ea87 |
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| Source note | uspto-grants-2011_03 |
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