HCID 68792732, compound → HCID 57470604, compound

HRID 602055Notes

Reaction equation

HRID 602055 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:17]([CH3:24])([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:5]=[C:6]([O:9]CC2C=CC=CC=2)[C:7]=1[F:8]>CCO>[F:1][C:2]1[CH:3]=[C:4]([C:17]([CH3:23])([CH3:24])[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:5]=[C:6]([OH:9])[C:7]=1[F:8]

Participants

3

Reactant 1

HCID 68792732HCID 68792732, compound

Product 1

HCID 57470604HCID 57470604, compoundYield 117.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 2-{3,4-difluoro-5-[(phenylmethyl)oxy]phenyl}-2-methylpropanoate (111 mg, 0.332 mmoles) in EtOH (2 mL) was degassed and flushed with N2. To the solution was added Pd/C (10% by weight) and a H2 balloon was attached. After overnight under H2, the solution was filtered through celite and concentrated to afford 95 mg of crude product purified by Biotage.

Workup

  1. customflushed with N2
  2. additionTo the solution was added Pd/C (10% by weight)
  3. filtrationthe solution was filtered through celite
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-67dd31d95383431786646a3369bf0d51
Source dataset
uspto-grants-2011_03
Patent number
US07902394B2

Reaction notes

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