反应详情

Trifluoroacetic acid (43 mL, 558 mmol) was added to benzyl 1-(tert-butoxycarbonyl)nipecotate (7.11 g, 22.3 mmol) in dichloromethane (20 mL). The mixture was stirred for 3 hours. Subsequently, the reaction mixture was concentrated and water was added to the residue, followed by addition of 1 mol/L aqueous sodium hydroxide solution to make the mixture basic. The mixture was then extracted with ethyl acetate. The organic layer washed with brine and was dried over sodium sulfate. The solvent was evaporated to give 5.97 g (quant.) of the desired compound as a yellow oil.

1. concentrationSubsequently, the reaction mixture was concentrated
2. additionwater was added to the residue
3. additionfollowed by addition of 1 mol/L aqueous sodium hydroxide solution
4. extractionThe mixture was then extracted with ethyl acetate
5. washThe organic layer washed with brine
6. dry with materialwas dried over sodium sulfate
7. customThe solvent was evaporated