HCID 57572194, compound → N-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyl]piperidine-3-carboxamide hydrochloride

HRID 602136Notes

Reaction equation

HRID 602136 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]([NH:16][CH2:17][C:18]2[S:22][C:21]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[N:20][C:19]=2[CH3:30])=[O:15])[CH2:9]1)=O)(C)(C)C>Cl.CO>[ClH:29].[Cl:29][C:26]1[CH:27]=[CH:28][C:23]([C:21]2[S:22][C:18]([CH2:17][NH:16][C:14]([CH:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)=[O:15])=[C:19]([CH3:30])[N:20]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 1

HCID 57572194HCID 57572194, compound

Product 1

HCID 67266868N-[[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]methyl]piperidine-3-carboxamide hydrochlorideYield 195.1%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

1-tert-Butoxycarbonyl-N-[[2-(4-chlorophenyl)-4-methylthiazol-5-yl]methyl]piperidine-3-carboxamide (916 mg, 2.04 mmol) was dissolved in a 10% hydrogen chloride/methanol solution (20 mL) and the mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was concentrated and the residue was air-dried to give 769 mg (98%) of the desired compound as a colorless amorphous product.

Workup

  1. concentrationSubsequently, the reaction mixture was concentrated
  2. customthe residue was air-dried

Sources & evidence

ORD record
ord-790c99f952394bab810576749e3fa729
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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