反应详情

Trifluoroacetic acid (2 mL) was added to methyl 3-[3-(tert-butoxycarbonylamino)piperidin-1-yl]benzoate (451 mg, 1.35 mmol) in dichloromethane (2 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the mixture was concentrated and a saturated aqueous sodium bicarbonate solution was added to the residue to make it basic. The mixture was extracted with ethyl acetate and the organic layer washed with brine and dried over magnesium sulfate. Evaporation of the solvent gave 158 mg (50%) of the desired compound as a pale yellow oil.

1. concentrationSubsequently, the mixture was concentrated
2. additiona saturated aqueous sodium bicarbonate solution was added to the residue
3. extractionThe mixture was extracted with ethyl acetate
4. washthe organic layer washed with brine
5. dry with materialdried over magnesium sulfate
6. customEvaporation of the solvent