反应详情

N-[[1-[2-(Methoxycarbonyl)phenyl]piperidin-3-yl]methyl]phthalimide (495 mg, 1.31 mmol) was dissolved in methanol (10 mL). To this solution, hydrazine monohydrate (190 μL) was added and the mixture was refluxed for 3 hours. Subsequently, the reaction mixture was diluted with water and extracted with ethylacetate. The organic layer washed with brine and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 253 mg (78%) of the desired compound as an orange oil.

1. temperaturethe mixture was refluxed for 3 hours
2. extractionextracted with ethylacetate
3. washThe organic layer washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customEvaporation of the solvent