4-Biphenylcarboxylic acid, 4'-chloro- → HCID 58992583, compound

HRID 602167Notes

Reaction equation

HRID 602167 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH2:4]1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32](O)=[O:33])=[CH:28][CH:27]=2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([NH:1][CH2:2][CH:3]3[CH2:8][CH2:7][CH2:6][N:5]([C:9]4[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=4)[C:12]([O:14][CH3:15])=[O:13])[CH2:4]3)=[O:33])=[CH:28][CH:27]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 6160024-Biphenylcarboxylic acid, 4'-chloro-HCID 58992672HCID 58992672, compound

Product 1

HCID 58992583HCID 58992583, compoundYield 82.3%

Procedure

Using methyl 3-[3-(aminomethyl)piperidin-1-yl]benzoate (76.2 mg, 0.307 mmol) and 4′-chlorobiphenyl-4-carboxylic acid (77.2 mg, 0.332 mmol), the same procedure was followed as in Step 61e of Example 61 to give 117 mg (82%) of the desired compound as a pale yellow powder.

Sources & evidence

ORD record
ord-64b5c4387a9d4abd84ae286c6f923938
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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