反应详情

In an argon atmosphere, 10% palladium on activated carbon (234 mg) and ammonium formate (1.66 g, 26.4 mmol) were added to 1-[3-(methoxycarbonyl)phenyl]benzyl nipecotate (2.34 g, 6.60 mmol) in methanol (50 mL). The reaction mixture was stirred at room temperature for 4 hours. Subsequently, the mixture was filtered through Celite and the filtrate was concentrated. 5% aqueous citric acid was added to the residue and the mixture was extracted with ethyl acetate. The organic layer was then washed with brine and was dried over sodium sulfate. The solvent was evaporated to give 1.57 g (90%) of the desired compound as a pale reddish brown powder.

1. filtrationSubsequently, the mixture was filtered through Celite
2. concentrationthe filtrate was concentrated
3. addition5% aqueous citric acid was added to the residue
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic layer was then washed with brine
6. dry with materialwas dried over sodium sulfate
7. customThe solvent was evaporated