4-(4-Fluorophenoxy)benzylchloride → 1-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine

HRID 602185Notes

Reaction equation

HRID 602185 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([OH:11])[CH2:6]1)=[O:4].[F:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][C:20]2[CH:27]=[CH:26][C:23]([CH2:24]Cl)=[CH:22][CH:21]=2)=[CH:17][CH:16]=1>>[F:13][C:2]([F:1])([F:12])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([O:11][CH2:24][C:23]2[CH:26]=[CH:27][C:20]([O:19][C:18]3[CH:28]=[CH:29][C:15]([F:14])=[CH:16][CH:17]=3)=[CH:21][CH:22]=2)[CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 222931364-(4-Fluorophenoxy)benzylchlorideHCID 589925842,2,2-Trifluoro-1-(3-hydroxypiperidin-1-yl)ethanone

Product 1

HCID 589925921-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidineYield 55%

Procedure

Using 1-trifluoroacetyl-3-hydroxypiperidine (394 mg, 2.00 mmol) and 4-(4-fluorophenoxy)benzylchloride (473 mg, 2.00 mmol), the same procedure was followed as in Step 6a of Example 6 to give 434 mg (55%) of the desired compound as a colorless oil.

Sources & evidence

ORD record
ord-e026718bce75451ba75be32f5aecf58b
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

Loading…