HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Fluorophenoxy)benzylchloride → 1-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Fluorophenoxy)benzylchloride | HCID 22293136 | — |
| Reactant | 2,2,2-Trifluoro-1-(3-hydroxypiperidin-1-yl)ethanone | HCID 58992584 | — |
| Product | 1-Trifluoroacetyl-3-[4-(4-fluorophenoxy)benzyloxy]piperidine | HCID 58992592 | 55% |
Reaction Steps
Using 1-trifluoroacetyl-3-hydroxypiperidine (394 mg, 2.00 mmol) and 4-(4-fluorophenoxy)benzylchloride (473 mg, 2.00 mmol), the same procedure was followed as in Step 6a of Example 6 to give 434 mg (55%) of the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902367B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-e026718bce75451ba75be32f5aecf58b |
| Source note | uspto-grants-2011_03 |