3-[4-(4-Fluorophenoxy)benzyloxy]piperidine → Methyl 3-[3-[[4-(4-fluorophenoxy)phenyl]methoxy]piperidin-1-yl]benzoate

HRID 602187Notes

Reaction equation

HRID 602187 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:20]=[CH:19][C:10]([CH2:11][O:12][CH:13]3[CH2:18][CH2:17][CH2:16][NH:15][CH2:14]3)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH3:23][O:24][C:25]([C:27]1[CH:28]=[C:29](OB(O)O)[CH:30]=[CH:31][CH:32]=1)=[O:26]>>[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:20]=[CH:19][C:10]([CH2:11][O:12][CH:13]3[CH2:18][CH2:17][CH2:16][N:15]([C:31]4[CH:32]=[C:27]([CH:28]=[CH:29][CH:30]=4)[C:25]([O:24][CH3:23])=[O:26])[CH2:14]3)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 589926953-[4-(4-Fluorophenoxy)benzyloxy]piperidineHCID 671702873-Methoxycarbonylphenylboric acid

Product 1

HCID 58992659Methyl 3-[3-[[4-(4-fluorophenoxy)phenyl]methoxy]piperidin-1-yl]benzoateYield 42%

Procedure

Using 3-[4-(4-fluorophenoxy)benzyloxy]piperidine (157 mg, 0.521 mmol) and 3-(methoxycarbonyl)phenylboric acid (187 mg, 1.04 mmol), the same procedure was followed as in Example 2 to give 94.8 mg (42%) of the desired compound as a colorless oil.

Sources & evidence

ORD record
ord-9fe8483d268b432081d988be7eb5d376
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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