3-(Boc-amino)piperidine → Methyl 3-benzyloxy-5-[3-(tert-butoxycarbonylamino)piperidin-1-yl]benzoate

HRID 602204Notes

Reaction equation

HRID 602204 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:15]([O:22][C:23]1[CH:24]=[C:25]([CH:30]=[C:31](OS(C(F)(F)F)(=O)=O)[CH:32]=1)[C:26]([O:28][CH3:29])=[O:27])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([O:22][C:23]1[CH:24]=[C:25]([CH:30]=[C:31]([N:11]2[CH2:12][CH2:13][CH2:14][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:10]2)[CH:32]=1)[C:26]([O:28][CH3:29])=[O:27])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 42330413-(Boc-amino)piperidineHCID 18945283Methyl 3-benzyloxy-5-(trifluoromethanesulfonyloxy)benzoate

Product 1

HCID 58992646Methyl 3-benzyloxy-5-[3-(tert-butoxycarbonylamino)piperidin-1-yl]benzoateYield 6%

Procedure

Using 3-(tert-butoxycarbonylamino)piperidine (301 mg, 1.50 mmol) and methyl 3-benzyloxy-5-(trifluoromethanesulfonyloxy)benzoate (595 mg, 1.52 mmol), the same procedure was followed as in Example 58 to give 39.7 mg (6.0%) of the desired compound as a brown oil.

Sources & evidence

ORD record
ord-8b90970646aa405ca444617ea50eabb7
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

Loading…