反应详情

Trifluoroacetic acid (1 mL) was added to tert-butyl 2-[2-[[2-(4-chlorophenyl)-4-methylthiazole-5-carbonyl]aminomethyl]morpholin-4-yl]benzoate (113 mg, 0.214 mmol) in dichloromethane (1 mL). The mixture was stirred at room temperature for 2 hours. Subsequently, the solvent was removed and a 1 mol/L aqueous potassium hydroxide solution was added to the residue to make it basic. The mixture was then made acidic by the addition of 2 mol/L hydrochloric acid. The crystallized powdery product was collected by filtration and washed with water to give 78.2 mg (78%) of the desired compound as a colorless powder.

1. customSubsequently, the solvent was removed
2. additiona 1 mol/L aqueous potassium hydroxide solution was added to the residue
3. additionmade acidic by the addition of 2 mol/L hydrochloric acid
4. filtrationThe crystallized powdery product was collected by filtration
5. washwashed with water