HCID 67267315, compound → HCID 57394350, compound

HRID 602214Notes

Reaction equation

HRID 602214 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH:14]=[CH:15][CH:16]3[CH2:21][CH2:20][CH2:19][N:18]([C:22]4[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=4)[C:25]([OH:27])=[O:26])[CH2:17]3)=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1.[H][H]>[Pd].O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:14][CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][N:18]([C:22]4[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=4)[C:25]([OH:27])=[O:26])[CH2:17]3)=[C:11]([CH3:13])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 67267315HCID 67267315, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57394350HCID 57394350, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

10% Palladium on activated carbon (5 mg) was added to 3-[3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidin-1-yl]benzoic acid (35.0 mg, 0.0797 mmol) in tetrahydrofuran (5 mL). The reaction mixture was stirred at room temperature for hours in a hydrogen atmosphere. Subsequently, the mixture was filtered through Celite and the solvent was evaporated to give 35.1 mg (quant.) of the desired compound as a colorless powder.

Workup

  1. filtrationSubsequently, the mixture was filtered through Celite
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-8809a4f78baa46699dbe192669e57d8c
Source dataset
uspto-grants-2011_03
Patent number
US07902367B2

Reaction notes

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