反应详情

2.8 g of (4a) (9.7 mmol), 1.1 g of acetonylacetone (9.7 mmol) and 0.5 mL of glacial AcOH in 50 mL of absolute ethanol are mixed under a nitrogen atmosphere. The mixture is heated to reflux for 6 h, the solvent is evaporated, the residue is redissolved with chloroform and water, the organic phase is washed with water, dried with Na2SO4 and evaporated. Product: 1.7 g. Formula: C20H19N5 (m.w. 329.41). Yield 54%.

1. temperatureThe mixture is heated
2. temperatureto reflux for 6 h
3. customthe solvent is evaporated
4. dissolutionthe residue is redissolved with chloroform and water
5. washthe organic phase is washed with water
6. dry with materialdried with Na2SO4
7. customevaporated