HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178425435, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2,5-Hexanedione | HCID 8035 | — |
| Reactant | N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]amine | HCID 178509559 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178425435 | HCID 178425435 | 54% |
Reaction Steps
2.8 g of (4a) (9.7 mmol), 1.1 g of acetonylacetone (9.7 mmol) and 0.5 mL of glacial AcOH in 50 mL of absolute ethanol are mixed under a nitrogen atmosphere. The mixture is heated to reflux for 6 h, the solvent is evaporated, the residue is redissolved with chloroform and water, the organic phase is washed with water, dried with Na2SO4 and evaporated. Product: 1.7 g. Formula: C20H19N5 (m.w. 329.41). Yield 54%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906501B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-f63bc9f83d7c4c51b63ac394a4aea222 |
| Source note | uspto-grants-2011_03 |