Hydrochloric Acid → HCID 66593188, compound

HRID 602320Notes

Reaction equation

HRID 602320 reaction equation
[ClH:1].[O:2]=[C:3]1[CH2:8][O:7][CH2:6][CH2:5][N:4]1[C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([CH:18]2[CH2:22][CH2:21][CH2:20][N:19]2C(OC(C)(C)C)=O)=[O:17])=[CH:11][CH:10]=1>O1CCOCC1>[ClH:1].[O:2]=[C:3]1[CH2:8][O:7][CH2:6][CH2:5][N:4]1[C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]([CH:18]2[CH2:22][CH2:21][CH2:20][NH:19]2)=[O:17])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66593142HCID 66593142, compound

Product 1

HCID 66593188HCID 66593188, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.2 40 ml of 4N hydrochloric acid in dioxane are added to a solution of 1.4 g (3.60 mmol) of tert-butyl 2-[4-(3-oxomorpholin-4-yl)phenyl-carbamoyl]pyrrolidine-1-carboxylate in 20 ml of dioxane, and the mixture is stirred at room temperature for 12 hours. The precipitate is subsequently filtered off with suction and washed successively with 10 ml of dioxane and 10 ml of diethyl ether and dried under reduced pressure, giving 1.1 g of N-[4-(3-oxomorpholin-4-yl)phenyl]pyrrolidine-2-carboxamide hydrochloride as a white powder; ESI 290.

Workup

  1. filtrationThe precipitate is subsequently filtered off with suction
  2. washwashed successively with 10 ml of dioxane and 10 ml of diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-33cf85b3592140a396372d7101afdc3f
Source dataset
uspto-grants-2011_03
Patent number
US07906516B2

Reaction notes

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