Methylamine → HCID 67270960, compound

HRID 602484Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([NH:13][C:14]([C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH:25]([CH3:27])[CH3:26])[N:17]=2)=[O:15])[CH2:10][C@H:9]1[CH2:28][C:29]([OH:31])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:32][NH2:33]>>[CH:25]([N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16]([C:14]([NH:13][C@@H:11]2[CH2:12][N:8]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[C@H:9]([CH2:28][C:29]([NH:33][CH3:32])=[O:31])[CH2:10]2)=[O:15])=[N:17]1)([CH3:27])[CH3:26]

Participants

Reactant 2

HCID 6329Methylamine

HCID 67271011HCID 67271011, compound

Product 1

HCID 67270960HCID 67270960, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 7 from ((2S,4S)-1-(tert-butoxycarbonyl)-4-{[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino}pyrrolidin-2-yl)acetic acid (step 1 of Example 13) and methylamine.

Sources & evidence

ORD record: ord-5d5d004946b94cee9bd4f33db1f7f50d
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906532B2

Reaction notes

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