Isobutyryl chloride → HCID 67271062, compound

HRID 602491Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C@@H:4]1[CH2:8][C@H:7]([NH:9][C:10]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH:21]([CH3:23])[CH3:22])[N:13]=2)=[O:11])[CH2:6][N:5]1[C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25].[C:31](Cl)(=[O:35])[CH:32]([CH3:34])[CH3:33]>>[C:31]([NH:1][CH2:2][CH2:3][C@@H:4]1[CH2:8][C@H:7]([NH:9][C:10]([C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]([CH:21]([CH3:23])[CH3:22])[N:13]=2)=[O:11])[CH2:6][N:5]1[C:24]([O:26][C:27]([CH3:28])([CH3:30])[CH3:29])=[O:25])(=[O:35])[CH:32]([CH3:34])[CH3:33]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 67271025HCID 67271025, compound

Product 1

HCID 67271062HCID 67271062, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of Example 17 from tert-butyl (2R,4S)-2-(2-aminoethyl)-4-{[(1-isopropyl-1H-indazol-3-yl)carbonyl]amino}pyrrolidine-1-carboxylate (Step 2 of Example 19) and isobutyryl chloride.

Sources & evidence

ORD record: ord-11a928458fa44d0689c47cd404c18193
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07906532B2

Reaction notes

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