Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-fluorophenyl)-N-methylmethanamine | HCID 736860 | — |
| Reactant | 4-Fluoro-1-nitro-2-(propan-2-yloxy)benzene | HCID 10631832 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 67267678 | HCID 67267678 | — |
Reaction Steps
4-Fluoro-2-isopropoxy-1-nitrobenzene (1.0 g) was dissolved in dry dimethylsulfoxide (25 mL). Potassium carbonate (1.4 g) and (4-fluorobenzyl)-(methyl)-amine (0.84 g) were added. The resulting mixture was heated to 90° C. over night. After cooling to room temperature, water (75 mL) was added, and the resulting mixture was extracted with ethyl acetate (3×75 mL). The organic phase was dried over sodium sulfate, filtered, and evaporated in vacuo to yield the title compound as slightly yellow solid (1.6 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07906537B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-668416f3893441f68de67ec79e3083f8 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
