反应详情

温度

90 °C

4-Fluoro-2-isopropoxy-1-nitrobenzene (1.0 g) was dissolved in dry dimethylsulfoxide (25 mL). Potassium carbonate (1.4 g) and (4-fluorobenzyl)-(methyl)-amine (0.84 g) were added. The resulting mixture was heated to 90° C. over night. After cooling to room temperature, water (75 mL) was added, and the resulting mixture was extracted with ethyl acetate (3×75 mL). The organic phase was dried over sodium sulfate, filtered, and evaporated in vacuo to yield the title compound as slightly yellow solid (1.6 g, 100%).

1. temperatureAfter cooling to room temperature
2. extractionthe resulting mixture was extracted with ethyl acetate (3×75 mL)
3. dry with materialThe organic phase was dried over sodium sulfate
4. filtrationfiltered
5. customevaporated in vacuo