HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67268071, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 67267943 | HCID 67267943 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | HCID 67268071 | HCID 67268071 | — |
Reaction Steps
A solution of 4.40 g ethyl 2-(3-tert-butoxycarbonylamino-piperidin-1-yl)-3-(but-2-ynyl)-3H-imidazole-4-carboxylate in 28 ml 4 M potassium hydroxide solution and 20 ml of tetrahydrofuran is stirred for 14 h at 100° C. Then the solution is neutralized with 2 M hydrochloric acid and extracted with dichloromethane. The combined organic extracts are dried over sodium sulphate and evaporated to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906539B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-fcc1f8ac5f234d34a877f4764d6f2956 |
| Source note | uspto-grants-2011_03 |