Hydrochloric Acid → HCID 67268071, compound

HRID 602734Notes

Reaction equation

HRID 602734 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][C:21]#[C:22][CH3:23])[C:18]([C:24]([O:26]CC)=[O:25])=[CH:17][N:16]=2)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl>[OH-].[K+].O1CCCC1>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][C:21]#[C:22][CH3:23])[C:18]([C:24]([OH:26])=[O:25])=[CH:17][N:16]=2)[CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67267943HCID 67267943, compound

Product 1

HCID 67268071HCID 67268071, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14797Potassium HydroxideSolvent

Procedure

A solution of 4.40 g ethyl 2-(3-tert-butoxycarbonylamino-piperidin-1-yl)-3-(but-2-ynyl)-3H-imidazole-4-carboxylate in 28 ml 4 M potassium hydroxide solution and 20 ml of tetrahydrofuran is stirred for 14 h at 100° C. Then the solution is neutralized with 2 M hydrochloric acid and extracted with dichloromethane. The combined organic extracts are dried over sodium sulphate and evaporated to dryness.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialThe combined organic extracts are dried over sodium sulphate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-fcc1f8ac5f234d34a877f4764d6f2956
Source dataset
uspto-grants-2011_03
Patent number
US07906539B2

Reaction notes

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