Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | HCID 67268920 | HCID 67268920 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59857703 | HCID 59857703 | — |
Reaction Steps
A mixture of 0.10 g 5-(3-methyl-but-2-en-1-ylamino)-[1,3,4]oxadiazole-2-carboxylic acid-(naphth-1-ylmethyl)-amide and 1.28 g piperazine is stirred for 15 min at 200° C. in a microwave. After cooling to ambient temperature dichloromethane is added, the organic phase is washed with water, dried over sodium sulphate and the solvent is removed. The residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→7:3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07906539B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-ab9fc9503091485eaa2faa997cdc2211 |
|---|
| Source note | uspto-grants-2011_03 |
|---|
