Piperazine → HCID 59857703, compound

HRID 602738Notes

Reaction equation

HRID 602738 reaction equation
[C:1]1([CH2:11][NH:12][C:13]([C:15]2O[C:17]([NH:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])=[N:18][N:19]=2)=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>ClCCl>[N:26]1([C:17]2[N:20]([CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])[C:15]([C:13]([NH:12][CH2:11][C:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH:4]=[CH:3][CH:2]=3)=[O:14])=[N:19][N:18]=2)[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 67268920HCID 67268920, compound

Product 1

HCID 59857703HCID 59857703, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
200 °C

Procedure

A mixture of 0.10 g 5-(3-methyl-but-2-en-1-ylamino)-[1,3,4]oxadiazole-2-carboxylic acid-(naphth-1-ylmethyl)-amide and 1.28 g piperazine is stirred for 15 min at 200° C. in a microwave. After cooling to ambient temperature dichloromethane is added, the organic phase is washed with water, dried over sodium sulphate and the solvent is removed. The residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→7:3).

Workup

  1. additionis added
  2. washthe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. customthe solvent is removed
  5. customThe residue is purified by chromatography on silica gel (dichloromethane/methanol 1:0→7:3)

Sources & evidence

ORD record
ord-ab9fc9503091485eaa2faa997cdc2211
Source dataset
uspto-grants-2011_03
Patent number
US07906539B2

Reaction notes

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