Methanol → Methyl azetidine-3-carboxylate hydrochloride

HRID 602829Notes

Reaction equation

HRID 602829 reaction equation
S(Cl)([Cl:3])=O.[NH:5]1[CH2:8][CH:7]([C:9]([OH:11])=[O:10])[CH2:6]1.[CH3:12]O>>[ClH:3].[NH:5]1[CH2:8][CH:7]([C:9]([O:11][CH3:12])=[O:10])[CH2:6]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 931923-azetidinecarboxylic Acid

Product 1

HCID 21100040Methyl azetidine-3-carboxylate hydrochloride

Procedure

Methanol (70 mL) was added dropwise under stirring at 0° C. to thionyl chloride (23.4 mL), and azetidine-3-carboxylic acid (CAS No. 36476-78-5, 25 g) was added, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated, to thereby obtain the title compound (36 g) having the following physical properties.

Workup

  1. addition36476-78-5, 25 g) was added
  2. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-e7e98087dab44e869a25841b8b47620d
Source dataset
uspto-grants-2011_03
Patent number
US07906549B2

Reaction notes

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