HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl azetidine-3-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-azetidinecarboxylic Acid | HCID 93192 | — |
| Product | Methyl azetidine-3-carboxylate hydrochloride | HCID 21100040 | — |
Reaction Steps
Methanol (70 mL) was added dropwise under stirring at 0° C. to thionyl chloride (23.4 mL), and azetidine-3-carboxylic acid (CAS No. 36476-78-5, 25 g) was added, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated, to thereby obtain the title compound (36 g) having the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07906549B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-e7e98087dab44e869a25841b8b47620d |
| Source note | uspto-grants-2011_03 |