Hydrochloric Acid → 2-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidine

HRID 602958Notes

Reaction equation

HRID 602958 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:9][C:7]=2[N:8]=1.Cl>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 670658712-(Methylthio)-6-trityl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

Product 1

HCID 670658482-(Methylthio)-6,7-dihydro-5H-pyrrolo[3,4-D]pyrimidine

Procedure

To 1.5 g of the product from Step A was added 15 mL (4.0 M in 1,4-dioxane) of hydrochloric acid and the solution stirred for 1 h and then concentrated in vacuo. The crude residue was chromatographed on a Biotage® system (silica gel, 0 to 50% methanol/ethyl acetate, 1% ammonium hydroxide) to give the title compound as a white solid. LC/MS 167.3 (M+1).

Workup

  1. concentrationconcentrated in vacuo
  2. customThe crude residue was chromatographed on a Biotage® system (silica gel, 0 to 50% methanol/ethyl acetate, 1% ammonium hydroxide)

Sources & evidence

ORD record
ord-26d37ff9bf7b423597ac3d6e5313fea5
Source dataset
uspto-grants-2011_03
Patent number
US07906649B2

Reaction notes

Loading…